The high expression of fibrin–fibronectin complexes, as the result of protein seepage of tumor vessels and the procoagulant effect in the tumor microenvironment (Abe et al., 1999; Wang et al., 2015), is related to many invasive and metastatic tumor phenotypes (Malik et al., 2010), including primary and metastatic brain tumors (Bardos et al., 1996). This evidence concerns the gene FN1 and neoplasm.