FN1 and brain neoplasm: The high expression of fibrin–fibronectin complexes, as the result of protein seepage of tumor vessels and the procoagulant effect in the tumor microenvironment (Abe et al., 1999; Wang et al., 2015), is related to many invasive and metastatic tumor phenotypes (Malik et al., 2010), including primary and metastatic brain tumors (Bardos et al., 1996).