MSH6 and neoplasm: Adding tumour location also improved the performance of PREMM5 for identifying MLH1 (AUC 0.92 [95% CI 0.88–0.97] vs. 0.80 [95% CI 0.71–0.89]) and MSH6 (AUC 0.75 [95% CI 0.65–0.84] vs. 0.69 [95% CI 0.58–0.80]) mutation carriers (Fig. 2).