Similar autophagosome-lysosome fusion defect may also occur in the Zika virus infection, since that a lot of genes required for the lysosomal fusion were down-regulated by the Zika virus infection (Li et al., 2016), such as RAB7 (a member of the Rab GTPase superfamily) (Pankiv et al., 2010) and genes of class C Vacuolar protein sorting (Vps)/HO motypic fusion and Protein Sorting (HOPS) tethering complex (Vps16, Vps18, Vps33) (Wurmser et al., 2000). This evidence concerns the gene PROS1 and Zika virus infectious disease.