KLK3 and metastatic neoplasm: Metastatic disease is usually not amenable to surgery.<h4>Case presentation</h4>The current report presents a unique case of in which the excision of a solitary pulmonary metastasis resulted in undetectable prostate-specific antigen.<h4>Conclusion</h4>This case and others suggest metastasectomy could be considered in cases with solitary metastasis, and physicians should have a careful discussion regarding risks and possible benefits from surgical excision.