There have been a number GWAS reporting the association of CCT with sequence variants near or within many genes, including ZNF469, COL5A1, RXRA- COL5A1, COL8A2, AKAP13, AVGR8, FOXO1, FNDC3B, TJP1, NR3C2, LRRK1, FDF9-SGCG, LCN12-PTGDS, ADAMTS6, CHSY1, HS3ST3B1-PMP22, GLT8D2, SMAD3, VKORC1L1, COL4A3, FAM46A-IBTK, LPAR1, ARID5B, TBL1XR1- KCNMB2, ARHGAP20-POU2AF1, C7ORF42, MPDZ-NF1B, USP37, GPR15, TIPARP and WNT10A [75-81]. Here, COL5A1 is linked to total early-onset cataract.