However, recent studies refute this theory as there is evidence of overexpression of inflammatory mediators such as cytokines and interleukin 6 (IL-6) in tears of KC patients [4, 5] and inflammation is currently considered by some researchers to play an at least contributing role in the pathogenesis of KC [6] to add to genetic and environmental factors [7]. This evidence concerns the gene IL6 and keratoconus.