SLURP1 and mal de Meleda: Moreover, addition of WT recombinant SLURP-1 (rSLURP-1) to cultures of T cells from MdM patients restored the normal T cell activation response, showing that SLURP-1 plays a key role during normal activation of T cells induced by immunological stimulation enhancing the actions of ACh via α7 nAChRs (125).