In this study, we applied a widely used mouse model of sepsis induced by cecal ligation and puncture (CLP) and investigated the therapeutic effects of HSYA on sepsis as well as its impact on peripheral blood CD4+ T lymphocytes apoptosis and the modulation of apoptosis-associated proteins Bax, Bcl-2, cleaved caspase-9, cleaved and caspase-3. This evidence concerns the gene CASP9 and Sepsis.