Moreover, it was reported that CON6 mice expressed a considerably reduced amount of 5-LO also in bone marrow and peritoneal monocytes/macrophages and that transplantation of CON6 or 5-LO+/− bone marrow to LDLR−/− mice had a similar effect on atherosclerosis (2- to 3-fold decrease) suggesting that the level of 5-LO in macrophages is responsible, at least in part, for the progression of atherosclerosis [65]. This evidence concerns the gene LDLR and atherosclerosis.