Recently, accumulating evidences revealed that PTENP1 was downregulated or deleted in various cancers, such as GC [9], hepatocellular carcinoma (HCC) [10], renal cell carcinoma [11], head and neck squamous cell carcinoma (HNSCC) [12], melanoma [13], endometrial cancer [14], and oral squamous cell carcinoma (OSCC) [15]. Here, PTENP1 is linked to head and neck squamous cell carcinoma.