In αTC1-specific DA peaks, we observed motif enrichment for Fox family member TF (Fox:Ebox dimer, Foxa2, Foxo1, and Foxp1), which are involved in islet alpha cell function as suggested by Foxp1/2/4 knockout mice developing hypoglycemia and having impaired glucagon secretion47, and Tal1/Scl, which targets Ldb148, a coregulator of the Lin11-Isl1-Mec3 (LIM)–homeodomain (HD) complex implicated in islet alpha, beta, and delta cell development49,50. The gene discussed is ISL1; the disease is Hypoglycemia.