Although the structure of a 14-3-3ζ chimera with a pseudophosphorylated peptide (S → E substitution) from the tumour suppressor LKB1 was reported recently (PDB ID 4ZDR), the mutation or non-optimal (longer) linker resulted in a surprising and most likely unspecific binding of a peptide, manifested by different binding to each of the two subunits of the 14-3-3 dimer present in the asymmetric unit45,46. Here, STK11 is linked to neoplasm.