CCN2 and heart failure: The consistent lack of associations between CCN2 and adverse clinical events in both the BAMI cohort, which had a relatively large number of adverse events and long-term follow-up, and the POSTEMI cohort with multiple sampling points, indicate that circulating CCN2 measured in the acute stages of STEMI does not add prognostic information for development of myocardial injury, heart failure, and later cardiovascular events.