When we considered medication type (MMI or PTU), the associations of two HLA alleles (HLA-B*38:02 and HLA-DRB1*08:03) and 2 SNPs (rs2596487 and rs1811197) with agranulocytosis were strengthened when patients with PTU-induced agranulocytosis were removed from the analysis (See Supplementary Tables S2 and S3). Here, HLA-DRB1 is linked to Absence of circulating granulocytes.