HLA-B*27:05 (P = 1.10 × 10−4), HLA-B*38:02 (P = 2.41 × 10−4) and HLA-DRB1*08:03(P = 1.57 × 10−3) were significantly associated with ATD-induced agranulocytosis after adjusting with Bonferroni’s correction (P < 3.57 × 10−3). The gene discussed is HLA-DRB1; the disease is Absence of circulating granulocytes.