First, rs4349859, which has been found to tag HLA-B*27 subtypes in patients of European descent with major ankylosing spondylitis33, was in high LD with HLA-B*27:05 in our population and showed a strong associations with ATD-induced agranulocytosis in a European population23 and agranulocytosis associated with levamisole-adulterated cocaine in Alberta and British Columbia populations34. This evidence concerns the gene HLA-B and Absence of circulating granulocytes.