On this basis, we hypothesized that: 1: The long term deprivation of BDNF and up-regulation of TNF-α in CA3 underline the co-comorbidity of the cognitive deficits, depressive, anxiety as well as the nociceptive behaviors; 2: The co-curative effects of WTD is dependent on CA3; 3. The gene discussed is TNF; the disease is Cognitive impairment.