We further conclusively demonstrate for the first time that the nature of CD4 T cell responses to stage-specific Mtb antigens to be strikingly different; wherein DosR latency antigen-specific regulatory IL10+ Th17 cells in blood during latent infection skew towards a pathogenic IFNγ+ Th17 phenotype evident in BAL or blood of subjects with pulmonary or extrapulmonary TB respectively. The gene discussed is IFNG; the disease is disease arising from reactivation of latent virus.