After 12 h of the intravenous administration of ∆msbBCy7OMVs to mice bearing CT26 tumor or normal mice, we measured the fluorescence intensity of Cy7 in whole body (Fig. 3a) and in different organs including the spleen, liver, kidney, lung, heart, intestine, and tumor (Fig. 3b and Supplementary Fig. 7). Here, DDX53 is linked to neoplasm.