In order to check whether the effect of FAM46C on cell survival and proliferation is general to MM cells, we silenced FAM46C expression in RPMI8226, a MM cell line expressing wild-type FAM46C. To this end, we derived stable cell lines transduced with lentiviral vectors expressing three different shRNA targeting FAM46C. Although the level of silencing was moderate (~ 50%, Fig. 4d), basically all shRNAs led to an moderately increased proliferation rate of RPMI8226 cell line as measured using CFSE cell tracer (Fig. 4e). This evidence concerns the gene TENT5C and Miyoshi myopathy.