Moreover, poly(A) tails were not extended in other cell lines derived from hematological malignancies, such as in Raji and HL60 transduced with FAM46C. Furthermore, SSR4 mRNA is polyadenylated at the 3′ end as revealed by analysis using RNase H cleavage assay with oligo(dT)25 followed by northern blot (Fig. 8b); similar molecular phenotypes were determined for the translocon-associated protein SSR2 (Signal Sequence Receptor, Beta) (Supplementary Fig. 8a, b). This evidence concerns the gene SSR2 and hematologic disorder.