In the same study, Gpx3 expression was significantly lower (0.74 fold, p = 0.009) compared to WT controls by disease end stage, a finding which was replicated in blood sera of sporadic ALS cases (n = 18) and controls (n = 35) (GPX3 0.41-fold lower, p = 0.008)14. This evidence concerns the gene GPX3 and amyotrophic lateral sclerosis.