Interestingly, removing the 141 genes comprising the top (adhesion and inflammatory) GO terms and performing secondary GO analysis identified the Wnt receptor signaling pathway as the top GO term, including the following annotated genes: Wnt2, Wnt10A, Dkk3, Sdc1, Wnt4, Nkd1, Nkd2, Ndp, Tgfb1l1, Axin2, and Cpz. This finding is consistent with prominent linkage of Wnt signaling to renal fibrosis (59) and potentially to renal repair (60). This evidence concerns the gene NKD2 and renal fibrosis.