The progenitors of ICC (KitlowCD44+CD34+InsR/IGF-1R+) could not develop mature cells (Kit+CD44+CD34−InsR/IGF-1R−) in the absence of insulin and IGF-1; and the survival and function of ICC would not be well preserved either [6,26]. The gene discussed is CD44; the disease is intrahepatic cholangiocarcinoma.