CEACAM5 and neoplasm: The anti-CEA/anti-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (DOTA) bispecific antibody exhibited low tumor targeting and rapid blood clearance in a xenograft mouse model, but the specific tumor uptake and low normal tissue accumulation of the BsAb still improved the efficacy of RIT [131].