MEDI-565 (AMG211, MT111), as a BiTE antibody mediating T cell-directed cytotoxicity towards CEA positive tumor cells, was positively correlated with CEA antigen density regardless of the mutational status of the tumor cell lines, including BRAF, KRAS, PTEN, PI3KCA, and TP53 [111]. This evidence concerns the gene BRAF and neoplasm.