COMT and psychotic disorder: Interestingly, for both DRD2 and COMT, gender-specific effects on psychosis have also been reported (e.g. [52,53]), as Zhang [10] and our study in psychosis proneness have found with ZNF804A. Also, as reviewed by Godar and Bortolato [54], sexual hormones (i.e. estrogens and androgens) influence differentially the development of schizophrenia-related symptoms hypothetically through the mediation of dopaminergic neurotransmission.