SIVmac239-infected 90-120-Ia+ animals exhibiting persistent viremia consistently select Gag206-216, Gag241-249, Gag373-380, Vif114-124, Nef9-19, Nef89-97, and Nef193-203 epitope-specific CD8+ T-cell escape mutations by a year post-infection [28,29]. Here, CD8A is linked to infection.