C5AR1 and allergic asthma: More specifically, C5aR1 expression was downregulated in airway and tissue alveolar macrophages, CD11b+ conventional (c)DCs and monocyte-derived (mo)DCs but upregulated in eosinophils in an OVA-induced allergic asthma experimental model using GFP-C5aR1fl/fl mice [8].