In contrast, no consistent age-related pattern in binding was observed in SIDS cases, with a trend for binding to increase with age observed in several nuclei including the DMX, HG, NTS and SUB, while significant age-related reductions in NK1R binding were observed in the DAO (p = <0.001) and MAO (p = 0.02) (Fig 4). The gene discussed is TACR1; the disease is sudden infant death syndrome.