Marfan syndrome (MFS), an autosomal dominant connective tissue disorder, is caused by mutations in the fibrillin-1 gene (FBN1).[1, 2] Fibrillin-1 is a major constituent of microfibrils, involved in elastic fiber formation.[3] Manifestations of MFS affect multiple organ systems including skeletal muscle, skin, the cardiovascular system (e.g. aortic dissection) and the eye.[4] Up to 54% of MFS patients have major ocular involvement,[5] and ocular findings may be crucial in establishing the diagnosis. Here, FBN1 is linked to Marfan syndrome.