Albuminuria is an early sign of diabetic nephropathy (DN), which occurs in 25% to 40% of patients with DM.[10,11] DN is now the leading cause of end-stage kidney disease (ESKD) in different countries.[12] Various studies found that urinary albumin excretion alone can predict cancer mortality even in people without diabetes.[13,14] In addition, albuminuria has been observed in patients with different types of cancers such as colorectal, lung, renal cell, breast, and non-Hodgkin lymphoma.[15–19]. This evidence concerns the gene ALB and cancer.