The genomic analysis of Barrett’s stem cells shows a broad and variable mutational spectrum: 25% of cases do not show typical cancer-related genomic changes; most of cases display patterns of deletions like those observed in EAC, but gene-amplifications were absent; importantly, the cases showing signs of low-grade dysplasia, exhibit p53 mutations or amplifications of proto-oncogenes and RTK [103]. The gene discussed is TP53; the disease is cancer.