These authors have reported the comparative exome sequencing of 11 EACs and 12 ESCCs [33] and observed that, while the mutational frequency at the level of the tumor suppressor TP53 was similar (73% in EAC and 92% in ESCC), NOTCH1 and NOTCH3 mutations were much more frequent among ESCC (33 and 25%, respectively) than EAC (0 and 9%, respectively) [24]. The gene discussed is NOTCH1; the disease is esophageal squamous cell carcinoma.