NFE2L2 and neoplasm: This analysis provided evidence about recurrent mutations at the level of: six well known tumor-associated genes, such as TP53, RB1, CDKN2A, PIK3CA, NOTCH1, NFE2L2; two not previously reported genes, such as ADAM29 and FAM135B; six histone regulator genes, such as MLL2 (KMTD2), MLL3 (KMT2C), ASH1L, SETD1B, CREBBP and EP300 [11].