NOTCH1 and esophageal squamous cell carcinoma: A recent study characterized at molecular level a population of sub-Saharan ESCC and showed in these patients, similar genetic aberrations as those reported in Asian and North American cohorts, including frequent mutations of TP53, CDKN2A, NFE2L2, CHEK2, NOTCH1, FAT1 and FBXW7 [55].