PIK3CA and neoplasm: Phylogenetic tree construction, based on the results of multiregion whole-exome sequencing, allowed to establish that most of truncal and clonal driver mutations occurred in tumor-suppressor genes, such as TP53, KMT2D and ZNI750; in contrast, half of the driver mutations located on the branches of tumor phylogenetic trees involve oncogenes, such as PIK3CA, NFE2L2, KIT and mTOR [60] (Figure 4).