In a study on prostate cancer cells, treatment with SFN (20 and 30 μM) significantly inhibited NF-κB transcriptional activity, nuclear transloction of p65, and gene expression of NFκB-regulated VEGF, cylcin D1, and Bcl-XL in PC-3 C4 cells [64]. This evidence concerns the gene NFKB1 and Familial prostate cancer.