ACTA1 and Obesity: On the other hand, maternal obesity compounded with the Mc4r KO genotype had decreased α-SMA (−0.73-fold, p < 0.01), TNF-α (−0.54-fold, p < 0.05), and IL6 (−0.56-fold, p < 0.05) (Figure 3d) hepatic mRNA levels in the offspring.