It has previously been shown that HS deoxygenates HbS rapidly, resulting in the formation of amorphous precipitates of short, randomly-oriented Hb fibers, while MS has been shown to deoxygenate Hb more gradually, resulting in the formation of long, organized Hb polymers characteristic of SCA [31,32]. The gene discussed is GSTM1; the disease is autosomal dominant cerebellar ataxia.