Furthermore, in a rat model of hepatocarginogenesis it was shown that early preneoplastic foci and nodules progressing to HCC are characterized by inhibition of oxidative phosphorylation and by enhanced glucose utilization to stimulate the pentose phosphate pathway; these changes are supported by increased expression of the mitochondrial chaperone TRAP1 and of NRF2 that induces the expression of G6PD [172]. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.