Recently, Friemel and coworkers reported the analysis of various tumor-related parameters (cell and tissue morphology, expression of various liver cell markers including CK7, CD44, alpha-fetoprotein, EpCAM and glutamine synthetase and mutations of TP53 and CTNNB1) in 120 different tumor areas derived from 23 HCCs. The gene discussed is TP53; the disease is neoplasm.