A recent report showed that SALL4 is frequently expressed in iCCs (58%): SALL4-positive iCC cases display more frequent lymph nodal metastasis and vasculature invasion; furthermore, strongly SLL4-positive iCCs had shorter survival, compared to moderately positive or SALL4-negative cases [162]. This evidence concerns the gene SALL4 and intrahepatic cholangiocarcinoma.