Genomic deletions and gains at the level of various chromosome regions have been described: focal amplifications affect 6p21 (locus for VEGFA) and 11q13 (loci for FGF3/4/19/CCND1); recurrent homozygous deletions involved several genes relevant for cancer cell biology, such as AXIN1, CDKN2A/CDKN2B, IRF2, MAP2K3, PTEN, RB1. This evidence concerns the gene CDKN2A and cancer.