TERT and hepatocellular carcinoma: Interestingly, multiple types of TERT genetic alterations are observed in HCC: a first type is represented by TERT promoter mutations, observed in 64% of HCV-related HCCs, in 59% of non-viral cases and 37% of HBV-positive cases; a second type is represented by TERT amplification observed in about 7% of cases; a third type is related to insertion of the HBV genome in the TERT locus, observed in 22% of HBV-positive HCCs [7].