GNAS and intrahepatic cholangiocarcinoma: The ICC-C1 subtype was enriched for mitotic checkpoint signaling pathways (suggesting a high chromosome instability), frequent TP53, KRAS, MYC and GNAS mutations and display PLK1 and ECT2 as key drivers; the ICC-C2 subtype is linked to obesity, T cell proliferation, and bile acid metabolism [40].