NFE2L2 and hepatocellular carcinoma: Many of the recurrent mutations observed at the level of various genes seem to play a relevant role in liver tumorigenesis: thus, some mutated genes, such as TERT, JAK1 and RPSK3 play a role in hepatoacarcinogenesis; other ones, like AXIN1, CTNNB1, NFE2L2 and KEAP1 play a role both in hepatocarcinogenesis and progression; finally, ARID1A and ARID2 mutations play a role in initiation and progression of HCC [11,72].