CCNE1 and cancer: Thus, Nault and coworkers have reported in some of these patients the clonal integration of adeno-associated virus type 2 (AAV2) at the level of some cancer driver genes, including CCNA2 (cyclin 2), TERT, CCNE1 (cyclin E1), TNSF10 and KMT2B, inducing overexpression of the target genes [17].