Other recent studies have shown that disruption of signaling pathways playing a key role in liver homeostasis (control of liver size) and differentiation status and plasticity of hepatocytes, such as Hippo-YAP and Neurofibromin 2, represents an important step in hepatocarcinogenesis and is able to induce HCC formation. This evidence concerns the gene YAP1 and hepatocellular carcinoma.