In this context, initial studies have shown that hepatocellular carcinomas may be subdivided into two different subgroups according to their positivity for EpCAM: EpCAM+ hepatocarcinomas displayed features typically observed at the level of hepatic progenitor cells, including the expression of a series of stem/progenitor cell markers, such as cytokeratin-19, c-kit and activated Wnt-beta catenin signaling; EpCAM− hepatocarcinomas exhibited features more typical of mature hepatocytes [140]. Here, EPCAM is linked to hepatocellular carcinoma.