CDKN2A and cancer: Frequent gene alterations were observed at the level of various genes playing a key role in cancer development, such as TP53, MYC, WNT, CTNNB1 (beta-catenin), cell-cycle related genes CCND1 (cyclin D1) and CDKN2A (cyclin-dependent kinase inhibitor 2A); furthermore, are frequently altered genes involved in the control of telomere stability (telomerase reverse transcriptase, TERT), in epigenetic mechanisms (IDH1 and IDH2) and chromatin remodeling (ARID1, ARID2, MLL, BAP1 and EZH2) [4,5].