TERT and hepatocellular carcinoma: The study of more than 600 HCC patients confirmed that TERT promoter mutations were the most common somatic mutation observed in these tumors, with a preferential occurrence in older patients, predominantly male, HCV positive; interestingly, TERT promoter-mutated HCCs displayed a strong co-occurrence of CDKN2A silencing by promoter hypermethylation [8].