In contrast, cluster 3 and 4 of patients displayed lower levels of expression of DNA reparation genes and exhibited longer overall survival and tumor-free progression; these tumors at molecular level were characterized by low frequency of TP53 cluster gene mutations and frequent mutations of the CTNNB1 cluster genes (particularly, group 3 of HCC tumors) [77]. Here, TP53 is linked to hepatocellular carcinoma.