A screen was done using a zebrafish transgenic line expressing c-MYC in thymocytes [24] using 4880 FDA-approved drugs from 4 different libraries (Lopac, ICCB, Prestwick and Spectrum collection) and a parallel screen was done on KOPT-k1 cells, a NOTCH1-dependent T-ALL cell line. The gene discussed is MYC; the disease is acute lymphoblastic leukemia.