Specifically, we evaluated the effect of hepatocyte-specific adeno-associated viral (AAV) serotype 8-mediated human apo A-I gene therapy (AAV8-A-I) on the cardiac structure and function and on the development of heart failure in C57BL/6 low-density lipoprotein receptor (LDLr)-deficient mice subjected to pressure overload. Here, LDLR is linked to heart failure.