For instance, the multifaceted function of H19 (sponging let7 [84], regulating methylation at a genome wide level [98], targeting CDK8-β-catenin signaling [86], and regulating the cell cycle [86]) in CRC makes it possible to tackle multiple oncogenic mechanisms with a single hit on this lncRNA. The gene discussed is CDK8; the disease is colorectal carcinoma.