FAS and cancer: BS isolated from various plants promotes apoptosis by increasing first apoptosis signal (Fas) levels and caspase-8 activity [8], phosphorylation of extracellular signal-regulating kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) [161], inhibition of cancer cell proliferation, even at low concentrations with no cytotoxic effect on noncancerous cells [152], modulation of antioxidant enzyme levels in pathogenesis [103], arresting of cells at G2/M phase in cancer cells [150], and decreasing free radical generation in vitro [102,162].