GRIN1 and Intellectual disability: Three genes featured most predominantly among these pathways: (a) GRIN1, encoding a member of the ionotropic class of glutamate receptors, implicated in learning and memory, as well as intellectual disability and schizophrenia; (b) CAMK2B, a gene also involved in glutamate signaling, synaptic plasticity, and dendritic remodeling; and (c) SHANK2, involved in the organization and structure of excitatory synapses, including glutamate receptors, which has been previously associated with autism and psychosis susceptibility (Homann et al., 2016).