Three genes featured most predominantly among these pathways: (a) GRIN1, encoding a member of the ionotropic class of glutamate receptors, implicated in learning and memory, as well as intellectual disability and schizophrenia; (b) CAMK2B, a gene also involved in glutamate signaling, synaptic plasticity, and dendritic remodeling; and (c) SHANK2, involved in the organization and structure of excitatory synapses, including glutamate receptors, which has been previously associated with autism and psychosis susceptibility (Homann et al., 2016). The gene discussed is SHANK2; the disease is autism.