TNFSF15 silencing before and after inoculation of ovarian cancer ID8 cells to mice markedly increases angiogenesis and tumor growth, suggesting downregulation of TNFSF15 by cancer cells and tumor infiltrating macrophages (TIMs) and lymphocytes is a pre-requisite for neovascularization in ovarian cancer (Deng et al., 2012). Here, TNFSF15 is linked to neoplasm.