For example, Hospicells expressing the cell surface markers CD9, CD10, CD29, CD146, and CD16 in stroma produce a large amount of nitrous oxide (NO), which suppresses CD4(+), CD8(+) and Vγ9Vδ2 T cell proliferation and cytokine production, eventually conferring chemoresistance on ovarian cancer cells (Martinet et al., 2010). This evidence concerns the gene CD4 and ovarian cancer.