F2R and ovarian cancer: MMP1-mediated activation of the G protein coupled receptor (GPCR) protease-activated receptor-1 (PAR1) stimulates ovarian cancer cells to release CCL2, IL-8, growth regulated oncogene-a (GROa), chemokines that induce endothelial cell proliferation, tube formation, angiogenesis, and metastasis in peritoneal mouse models of ovarian cancer (Agarwal et al., 2010).