Synthesis of tumor-promoting factors including CCL2 and IL-6 is minimized in TAMs and ovarian cancer cells upon treatment by Trabectedin (Yondelis), an agent that originates from the tunicate Ecteinascidia turbinate, binds DNA minor grooves and inhibits monocyte differentiation into macrophage (Allavena et al., 2005). The gene discussed is CCL2; the disease is ovarian carcinoma.