MMP1-mediated activation of the G protein coupled receptor (GPCR) protease-activated receptor-1 (PAR1) stimulates ovarian cancer cells to release CCL2, IL-8, growth regulated oncogene-a (GROa), chemokines that induce endothelial cell proliferation, tube formation, angiogenesis, and metastasis in peritoneal mouse models of ovarian cancer (Agarwal et al., 2010). This evidence concerns the gene F2R and ovarian carcinoma.