Synthesis of tumor-promoting factors including CCL2 and IL-6 is minimized in TAMs and ovarian cancer cells upon treatment by Trabectedin (Yondelis), an agent that originates from the tunicate Ecteinascidia turbinate, binds DNA minor grooves and inhibits monocyte differentiation into macrophage (Allavena et al., 2005). This evidence concerns the gene IL6 and neoplasm.