KLRK1 and ovarian cancer: In ovarian cancer ascites, two main pathways that suppress NKG2D and NKp30 activity have been recognized. Specifically, migration inhibitory factor (MIF) promotes the immune escape of ovarian cancer cells by transcriptionally down-regulating NKG2D in vitro and in vivo, thus impairing NK cell cytotoxicity towards neoplastic cells (Krockenberger et al., 2008).