TEK and neoplasm: Increasing interest has emerged in targeting angiopoietin growth factors (mainly Ang1, Ang2, Ang4) that promote CAF accumulation and tumor angiogenesis in the TME, while Tie1 and Tie2 (also as TEK) receptors that regulate the maturation and plasticity of blood vessels are also considered as valuable targets (Augustin et al., 2009; Brunckhorst et al., 2014).