As supporting evidence, upon co-culture of TAMs and ovarian cancer cell line SKOV3, TAMs significantly upregulated MMP2, MMP9, and MMP10 expression and enhanced SKOV3 cell invasion via TLRs signaling pathway, validating the positive association of TAMs with metastasis and advancement of human ovarian cancer (Ke et al., 2016). The gene discussed is MMP2; the disease is ovarian carcinoma.