A2AR agonist increases CF in both ApoE KO and ApoE KO + HFD mice through increased activation of A2AR [19], while coronary reactive hyperemia is impaired in female ApoE KO + HFD as compared to WT mice, suggesting a compensatory mechanism for adenosine receptor-mediated coronary microvascular regulation in atherosclerosis [20]. The gene discussed is APOE; the disease is atherosclerosis.