IL6 and Hypoglycemia: Due to methodological limitations, the mechanism causing the increase in IL-6 concentrations could not be isolated but exercise intensity and duration (Gokhale et al. 2007), the occurrence of hypoglycaemia (Dotson et al. 2008) and supraphysiological doses of epinephrine (Helge et al. 2003) have been shown to modulate the circulatory appearance of IL-6 or IL-6 mRNA expression.