Adjustment for current CD4, undetectable HIV RNA level, cumulative HAART, and cumulative dideoxynucleoside use in the multivariable logistic regression analysis did not alter our findings for adiponectin (OR = 0.65; 95% confidence interval [CI], 0.44–0.97) or ICAM-1 (OR = 2.79; 95% CI, 1.16–6.67) but did attenuate the association of osteoprotegerin with fatty liver (OR = 0.53; 95% CI, 0.26–1.09). Here, CD4 is linked to fatty liver disease.