To determine whether these associations were mediated by VAT, we added VAT as a covariate in the model and found that the associations with fatty liver were attenuated but persisted for ICAM-1 (OR = 5.30, P = .004), CRP (OR = 1.66, P = .002), IL-6 (OR = 1.67, P = .03), TNFαR2 (OR = 6.55, P = .003), and adiponectin (OR = 0.51, P = .02), whereas the relationships of sCD163 and leptin levels with fatty liver were no longer statistically significant. This evidence concerns the gene LEP and fatty liver disease.