Among HIV-uninfected men, after adjustment for age, race, MACS site, and PNPLA3 genotype, we found a greater odds of fatty liver with higher levels of ICAM-1 (OR = 8.18, P < .001), CRP (OR = 2.02, P < .001), IL-6 (OR = 1.67, P = .004), TNFαR2 (OR = 9.11, P < .001), sCD163 (OR = 2.99, P = .01), and leptin (OR = 3.10, P = .002), and a lower odds of fatty liver with higher adiponectin levels (OR = 0.45, P = .002) (Figure 1, Table 3). This evidence concerns the gene IL6 and fatty liver disease.