Levels of FOXE1 and PAX8 messenger RNA (mRNA) in thyroid nodules have been found to be decreased in malignant thyroid lesions and higher in benign lesions, and even the gene expression patterns of FOXE1 and PAX8 can help in differentiating FTC from MTC and the Follicular Variant of Papillary Thyroid Carcinoma (FVPTC) [27]. The gene discussed is PAX8; the disease is thyroid nodule.