Moreover, as its role with the expression of TG and TPO suggests, mutations at the FOXE1 locus in 9q22 have been associated with thyroid disorders such as congenital HT due to thyroid dysgenesis, primary HT, goiters, nonmedullary thyroid cancer, PTC, and TC [5, 8]. The gene discussed is TPO; the disease is hypothyroidism, congenital, nongoitrous, 2.