FOXE1 is responsible for palatogenesis, and it appears that casual mutations in noncoding regions that regulate FOXE1 expression are related to CL and CP [3], such as SNPs rs7850258, rs12342417, and rs10984103 within the FOXE1 locus that have been associated with high risk for orofacial clefting [8]. The gene discussed is FOXE1; the disease is orofacial cleft.