Evidence of the link between stress and depression has prompted investigators to derive animal research models of stress (e.g., immobilization, unpredictable chronic stress, foot shock, social isolation, social defeat, restraint, forced swim, and maternal deprivation) to determine a cause and effect relationship between pathology, interventions, BDNF, and depressive symptoms (for excellent reviews of depression metrics in animals, see [108–114]). The gene discussed is BDNF; the disease is major depressive disorder.