The ability of PA to enhance BDNF release and function in the synapse, promote dendritic spine integrity, and activate other cellular pathways that contribute to plasticity [19, 24, 255] is vital for homeostatic processes that are necessary for the maintenance, repair, and reorganization of circuits damaged during depression, effects that recapitulate those of antidepressant drugs. Here, BDNF is linked to depressive symptom measurement.