NF1 and gastrointestinal stromal tumor: Since the majority of “wild-type” GISTs are now identified as having genetic or epigenetic loss of succinate dehydrogenase (SDH) subunits, the more accurate term is generally “SDH-deficient GIST”, unless there is some other rare mutation such asBRAF V600E, NF1 deletions, orNTRK fusions.