IFNA1 and coronary artery disorder: The following issues remain to be resolved: (i) optimal dose and duration for use in human CHD needs to be established; (ii) superiority of combination treatment of Myrcludex B with peg-IFN over peg-IFN monotherapy needs to be convincingly shown; (iv) safety appears to be of less concern, but the effect on bile acids has to be explored in a larger patient group; (v) efforts for replacing a daily subcutaneous formulation with an oral formulation should be seriously considered – this would enable long-term use.