Several humoral biomarkers have been correlated with protection against infection and disease in child cohorts evaluating natural infections and/or in early vaccine trials (serum and/or stool serotype-specific neutralizing antibodies, total IgA and IgG non-neutralizing RV-specific antibodies, and RV-secretory IgG and RV-specific T cells in animal models)11. This evidence concerns the gene CD79A and infection.