In clinical terms, this model has been corroborated by the main findings that, in a Brazilian endemic form of PF known as fogo selvagem, patients in the preclinical stage exhibit IgG1 autoAb against the EC5 domain of DSG1, and that the onset of disease is accompanied by the emergence of IgG4 autoAb recognizing the EC1 and EC2 domains of the molecule (22). Here, DSG1 is linked to pemphigus foliaceus.