XBP1 is genetically associated with UC, where deletion of XBP1 affects the intestinal epithelium and results in spontaneous intestinal inflammation (Adolph et al., 2013) and XBP1ΔIEC mice have aggravated dextran sodium sulfate (DSS)-induced colitis compared to wild-type mice (Kaser et al., 2008). The gene discussed is XBP1; the disease is colitis.