Additionally, treatment of cancer cells with these ethanol and acetone pulp extracts showed a noticeable reduction in colony and sphere formation with concomitant inhibition of cancer stemness associated genes CD44 and BMI-1 at their transcript levels, suggesting a preventive role of these pulp extracts in cancer stemness (Monteiro and Fodde, 2010), a pivotal property responsible for metastasis, therapy resistance and tumor recurrence (Figures 7, 8). The gene discussed is BMI1; the disease is cancer.