PFKFB3 and age-related macular degeneration: Reduction of glycolysis using an inhibitor of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase isoform 3 (PFKFB3) or endothelial-specific genetic deletion of Pfkfb3 inhibits pathological angiogenesis in murine models of AMD and oxygen-induced retinopathy (OIR), respectively9, 10.